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Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis

Alessandra Schiavo, Francesca M. Stagnaro, Andrea Salzano, Alberto M. Marra, Emanuele Bobbio, Pietro Valente, Simona Grassi, Martina Miniero, Michele Arcopinto, Margherita Matarazzo, Raffaele Napoli, Antonio Cittadini
  • Alessandra Schiavo
    Federico II University School of Medicine, Italy
  • Francesca M. Stagnaro
    Federico II University School of Medicine, Italy
  • Alberto M. Marra
    IRCCS SDN, Italy
  • Emanuele Bobbio
    Federico II University School of Medicine, Italy
  • Pietro Valente
    Federico II University School of Medicine, Italy
  • Simona Grassi
    Federico II University School of Medicine, Italy
  • Martina Miniero
    Federico II University School of Medicine, Italy
  • Michele Arcopinto
    Federico II University School of Medicine, Italy
  • Margherita Matarazzo
    Federico II University School of Medicine, Italy
  • Raffaele Napoli
    Federico II University School of Medicine, Italy

Abstract

Pregabalin, widely used in the treatment of several pain disorders, is usually well tolerated. Uncommonly, the drug may induce cardiac side effects, rarely prolongation of the PR interval. The latter has never been described in patients with healthy heart or normal renal function. We characterize a unique case of a young man with extrapulmonary tuberculosis and no detectable or known cardiac or kidney diseases, treated with pregabalin to control the severe pain due to the involvement of the spinal cord by the tuberculosis, showing an atrioventricular (AV) block due to pregabalin administration. The reported case emphasizes the need of monitoring PR interval during treatment with pregabalin, even in patients without background of cardiac or renal diseases. 

Keywords

Pregabalin; atrioventricular block; cardiovascular side effects; tuberculosis; pain.

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Submitted: 2017-05-18 16:33:31
Published: 2017-09-28 13:39:45
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Copyright (c) 2017 Alessandra Schiavo, Francesca M. Stagnaro, Andrea Salzano, Alberto M. Marra, Emanuele Bobbio, Pietro Valente, Simona Grassi, Martina Miniero, Michele Arcopinto, Margherita Matarazzo, Raffaele Napoli, Antonio Cittadini

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